Assay Detail
Binding
CHEMBL756572
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the binding affinity towards opioid receptor from rat whole brain using [3H]etorpine (33.2 Ci/mmol,0.2nanoM)as radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.53 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101535 | — | — | 1 | 10.00 |
| CHEMBL320880 | — | — | 1 | 9.22 |
| CHEMBL102175 | — | — | 1 | 8.51 |
| CHEMBL323088 | — | — | 1 | 8.48 |
| CHEMBL418802 | — | — | 1 | 8.37 |
| CHEMBL318166 | — | — | 1 | 7.84 |
| CHEMBL106283 | — | — | 1 | 6.88 |
| CHEMBL103983 | — | — | 1 | 6.28 |
| CHEMBL318374 | — | — | 1 | 6.12 |
| CHEMBL319023 | — | — | 1 | 5.62 |
| CHEMBL101483 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101535 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL320880 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL102175 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL323088 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL418802 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL318166 | — | Ki | = | 14.4 | nM | 7.84 |
| CHEMBL106283 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL103983 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL318374 | — | Ki | = | 765.0 | nM | 6.12 |
| CHEMBL319023 | — | Ki | = | 2425.0 | nM | 5.62 |
| CHEMBL101483 | — | Ki | = | 3231.0 | nM | 5.49 |