Assay Detail
Binding
CHEMBL756645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for Opioid receptor mu 1 by displacement of [3H]- DAGO
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 5.38 | 6.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93041 | — | — | 1 | 6.56 |
| CHEMBL104842 | — | — | 1 | 6.42 |
| CHEMBL106853 | — | — | 1 | 6.29 |
| CHEMBL107386 | — | — | 1 | 6.02 |
| CHEMBL107644 | — | — | 1 | 5.88 |
| CHEMBL2370386 | — | — | 1 | 5.82 |
| CHEMBL107754 | — | — | 1 | 5.70 |
| CHEMBL104436 | — | — | 1 | 5.61 |
| CHEMBL3038229 | — | — | 1 | 5.59 |
| CHEMBL571492 | — | — | 2 | 5.48 |
| CHEMBL2370384 | — | — | 1 | 5.24 |
| CHEMBL2370388 | — | — | 1 | 5.23 |
| CHEMBL104705 | — | — | 1 | 4.94 |
| CHEMBL104171 | — | — | 1 | 4.91 |
| CHEMBL318395 | — | — | 1 | 4.88 |
| CHEMBL2370390 | — | — | 1 | 4.72 |
| CHEMBL2370387 | — | — | 1 | 4.72 |
| CHEMBL485576 | — | — | 1 | 4.55 |
| CHEMBL105263 | — | — | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93041 | — | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL104842 | — | Ki | = | 379.4 | nM | 6.42 |
| CHEMBL106853 | — | Ki | = | 511.4 | nM | 6.29 |
| CHEMBL107386 | — | Ki | = | 954.9 | nM | 6.02 |
| CHEMBL107644 | — | Ki | = | 1329.0 | nM | 5.88 |
| CHEMBL2370386 | — | Ki | = | 1520.0 | nM | 5.82 |
| CHEMBL107754 | — | Ki | = | 2003.0 | nM | 5.70 |
| CHEMBL104436 | — | Ki | = | 2435.0 | nM | 5.61 |
| CHEMBL3038229 | — | Ki | = | 2555.0 | nM | 5.59 |
| CHEMBL571492 | — | Ki | = | 3320.0 | nM | 5.48 |
| CHEMBL2370384 | — | Ki | = | 5810.0 | nM | 5.24 |
| CHEMBL2370388 | — | Ki | = | 5853.0 | nM | 5.23 |
| CHEMBL571492 | — | Ki | = | 10962.0 | nM | 4.96 |
| CHEMBL104705 | — | Ki | = | 11523.0 | nM | 4.94 |
| CHEMBL104171 | — | Ki | = | 12386.0 | nM | 4.91 |
| CHEMBL318395 | — | Ki | = | 13089.0 | nM | 4.88 |
| CHEMBL2370390 | — | Ki | = | 18956.0 | nM | 4.72 |
| CHEMBL2370387 | — | Ki | = | 19210.0 | nM | 4.72 |
| CHEMBL485576 | — | Ki | = | 28411.0 | nM | 4.55 |
| CHEMBL105263 | — | Ki | = | 71373.0 | nM | 4.15 |