Assay Detail
Binding
CHEMBL756649
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Inhibition of [3H]DAMGO binding to mu opioid receptor of rat brain membranes
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3-(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-alkyl-N-arylbenzamides: potent, non-peptidic agonists of both the micro and delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.58 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155892 | — | — | 2 | 9.34 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 9.00 |
| CHEMBL156584 | — | — | 1 | 8.97 |
| CHEMBL434075 | — | — | 1 | 8.83 |
| CHEMBL596 | FENTANYL | 4.0 | 1 | 8.82 |
| CHEMBL345683 | — | — | 1 | 8.81 |
| CHEMBL157294 | — | — | 1 | 8.80 |
| CHEMBL158205 | — | — | 1 | 8.74 |
| CHEMBL422877 | — | — | 1 | 8.67 |
| CHEMBL156440 | — | — | 1 | 8.66 |
| CHEMBL346514 | — | — | 1 | 8.63 |
| CHEMBL157095 | — | — | 1 | 8.62 |
| CHEMBL157660 | — | — | 1 | 8.59 |
| CHEMBL156230 | — | — | 1 | 8.56 |
| CHEMBL345431 | — | — | 1 | 8.56 |
| CHEMBL348415 | — | — | 1 | 8.49 |
| CHEMBL349120 | — | — | 1 | 8.47 |
| CHEMBL155797 | — | — | 1 | 8.46 |
| CHEMBL348585 | — | — | 1 | 8.15 |
| CHEMBL346987 | — | — | 1 | 8.15 |
| CHEMBL155748 | — | — | 1 | 8.05 |
| CHEMBL25230 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155892 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL70 | MORPHINE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL156584 | — | Ki | = | 1.06 | nM | 8.97 |
| CHEMBL434075 | — | Ki | = | 1.49 | nM | 8.83 |
| CHEMBL596 | FENTANYL | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL345683 | — | Ki | = | 1.55 | nM | 8.81 |
| CHEMBL157294 | — | Ki | = | 1.58 | nM | 8.80 |
| CHEMBL158205 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL422877 | — | Ki | = | 2.16 | nM | 8.67 |
| CHEMBL156440 | — | Ki | = | 2.19 | nM | 8.66 |
| CHEMBL346514 | — | Ki | = | 2.35 | nM | 8.63 |
| CHEMBL157095 | — | Ki | = | 2.37 | nM | 8.62 |
| CHEMBL157660 | — | Ki | = | 2.55 | nM | 8.59 |
| CHEMBL156230 | — | Ki | = | 2.74 | nM | 8.56 |
| CHEMBL345431 | — | Ki | = | 2.78 | nM | 8.56 |
| CHEMBL348415 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL349120 | — | Ki | = | 3.39 | nM | 8.47 |
| CHEMBL155797 | — | Ki | = | 3.46 | nM | 8.46 |
| CHEMBL348585 | — | Ki | = | 7.06 | nM | 8.15 |
| CHEMBL346987 | — | Ki | = | 7.08 | nM | 8.15 |
| CHEMBL155892 | — | Ki | = | 7.56 | nM | 8.12 |
| CHEMBL155748 | — | Ki | = | 8.88 | nM | 8.05 |
| CHEMBL25230 | — | Ki | = | 15.0 | nM | 7.82 |