Assay Detail
Binding
CHEMBL756697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO at mu-opioid receptor
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.90 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1237164 | NALTRINDOLE HYDROCHLORIDE | — | 1 | 7.57 |
| CHEMBL401093 | OXYMORPHINDOLE | — | 1 | 7.18 |
| CHEMBL611695 | — | — | 1 | 6.15 |
| CHEMBL611702 | — | — | 1 | 5.92 |
| CHEMBL611703 | — | — | 1 | 5.89 |
| CHEMBL611700 | — | — | 1 | 5.89 |
| CHEMBL611704 | — | — | 1 | 5.60 |
| CHEMBL608241 | — | — | 1 | 5.58 |
| CHEMBL611696 | — | — | 1 | 5.55 |
| CHEMBL611701 | — | — | 1 | 5.55 |
| CHEMBL611699 | — | — | 1 | 5.34 |
| CHEMBL611705 | — | — | 1 | 5.34 |
| CHEMBL611697 | — | — | 1 | 5.10 |
| CHEMBL611698 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1237164 | NALTRINDOLE HYDROCHLORIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL401093 | OXYMORPHINDOLE | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL611695 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL611702 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL611703 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL611700 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL611704 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL608241 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL611696 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL611701 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL611699 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL611705 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL611697 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL611698 | — | Ki | > | 6600.0 | nM | - |