Assay Detail
Binding
CHEMBL756758
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Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from pig liver
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.74 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64906 | — | — | 1 | 6.30 |
| CHEMBL63335 | — | — | 1 | 5.85 |
| CHEMBL64905 | — | — | 1 | 5.82 |
| CHEMBL66528 | — | — | 1 | 5.36 |
| CHEMBL66527 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64906 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL63335 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL64905 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL66528 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL66527 | — | Ki | = | 4500.0 | nM | 5.35 |