Assay Detail
Binding
CHEMBL756760
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Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from rat liver
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.80 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64905 | — | — | 1 | 7.30 |
| CHEMBL63335 | — | — | 1 | 6.58 |
| CHEMBL66528 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64905 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL63335 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL66528 | — | IC50 | = | 300.0 | nM | 6.52 |