Assay Detail
Binding
CHEMBL756941
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Inhibition of canine kidney Phosphodiesterase 4 (PDE4)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.24 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431377 | — | — | 1 | 6.70 |
| CHEMBL308249 | — | — | 1 | 6.16 |
| CHEMBL18745 | — | — | 1 | 5.32 |
| CHEMBL305617 | — | — | 1 | 5.28 |
| CHEMBL70569 | — | — | 1 | 5.24 |
| CHEMBL68152 | — | — | 1 | 5.09 |
| CHEMBL304161 | — | — | 1 | 5.05 |
| CHEMBL305988 | — | — | 1 | 4.24 |
| CHEMBL278644 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431377 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL308249 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL18745 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL305617 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL70569 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL68152 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL304161 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL305988 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL278644 | — | IC50 | = | 82000.0 | nM | 4.09 |