Assay Detail
Functional
CHEMBL756954
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Calcium antagonistic activity was evaluated from the inhibition of CaCl2-induced contraction of depolarized pig coronary artery
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Tissue | Coronary artery |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
New 1,4-dihydropyridine derivatives combining calcium antagonism and alpha-adrenolytic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.11 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 9.52 |
| CHEMBL3350238 | — | — | 2 | 8.82 |
| CHEMBL2093965 | — | — | 1 | 8.60 |
| CHEMBL553942 | — | — | 1 | 8.42 |
| CHEMBL540511 | — | — | 1 | 8.40 |
| CHEMBL30911 | — | — | 1 | 8.40 |
| CHEMBL554455 | — | — | 1 | 8.35 |
| CHEMBL542812 | — | — | 1 | 7.89 |
| CHEMBL542814 | — | — | 1 | 6.82 |
| CHEMBL284056 | — | — | 1 | 6.00 |
| CHEMBL554235 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1484 | NICARDIPINE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3350238 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2093965 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL553942 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL540511 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL30911 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL554455 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3350238 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL542812 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL542814 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL284056 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL554235 | — | IC50 | > | 10000.0 | nM | - |