Assay Detail
Functional
CHEMBL756956
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In vitro inhibition of maximum porcine tubulin assembly rate after 20 min at 37 degrees C
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Publication
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.92 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | 4.0 | 1 | 6.89 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.46 |
| CHEMBL112192 | — | — | 1 | 6.37 |
| CHEMBL115499 | — | — | 1 | 6.32 |
| CHEMBL324797 | — | — | 1 | 6.20 |
| CHEMBL321632 | — | — | 1 | 6.20 |
| CHEMBL116173 | — | — | 1 | 6.17 |
| CHEMBL112385 | — | — | 1 | 6.12 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 6.12 |
| CHEMBL115488 | — | — | 1 | 6.04 |
| CHEMBL419387 | — | — | 1 | 6.04 |
| CHEMBL113332 | — | — | 1 | 5.92 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.85 |
| CHEMBL326388 | — | — | 1 | 5.77 |
| CHEMBL115360 | — | — | 1 | 5.75 |
| CHEMBL114642 | — | — | 1 | 5.64 |
| CHEMBL114651 | — | — | 1 | 5.60 |
| CHEMBL326114 | — | — | 1 | 5.58 |
| CHEMBL267340 | — | — | 1 | 5.36 |
| CHEMBL422965 | — | — | 1 | 5.00 |
| CHEMBL114937 | — | — | 1 | 5.00 |
| CHEMBL420862 | — | — | 1 | - |
| CHEMBL326395 | — | — | 1 | - |
| CHEMBL115002 | — | — | 1 | - |
| CHEMBL115490 | — | — | 1 | - |
| CHEMBL114423 | — | — | 1 | - |
| CHEMBL114677 | — | — | 1 | - |
| CHEMBL115451 | — | — | 1 | - |
| CHEMBL327061 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL61 | PODOFILOX | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL112192 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL115499 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL324797 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL321632 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL116173 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL112385 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL115488 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL419387 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL113332 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL326388 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL115360 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL114642 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL114651 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL326114 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL267340 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL422965 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL114937 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL420862 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL326395 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL115002 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL115490 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL114423 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL114677 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL115451 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL327061 | — | IC50 | > | 10000.0 | nM | - |