Assay Detail
Functional
CHEMBL756957
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In vitro inhibition of Cu2+ catalyzed LDL oxidation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.21 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317749 | TERBUFICIN | 2.0 | 1 | 6.96 |
| CHEMBL101229 | — | — | 1 | 6.82 |
| CHEMBL608 | PROBUCOL | 4.0 | 1 | 6.30 |
| CHEMBL101025 | — | — | 1 | 6.00 |
| CHEMBL321768 | — | — | 1 | 5.96 |
| CHEMBL177545 | — | — | 1 | 5.22 |
| CHEMBL102168 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317749 | TERBUFICIN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL101229 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL608 | PROBUCOL | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL101025 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL321768 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL177545 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL102168 | — | IC50 | > | 10000.0 | nM | - |