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Assay Detail

CHEMBL756958

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of [14C]- aminopyrine accumulation was determined in gastric vesicles of pig with outside vesicle pH 7
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Sus scrofa
Tissue Stomach
Confidence 1 — Organism
Curated By Expert

Target

Sus scrofa (CHEMBL613488)
Type ORGANISM
Organism Sus scrofa

Publication

Reversible inhibitors of the gastric (H+/K+)-ATPase. 1. 1-Aryl-4-methylpyrrolo[3,2-c]quinolines as conformationally restrained analogues of 4-(arylamino)quinolines.
Brown TH, Ife RJ, Keeling DJ, Laing SM, Leach CA, Parsons ME, Price CA, Reavill DR, Wiggall KJ.
J Med Chem (1990) 33 : 527 -533
PubMed 2153816 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.99 7.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL47529 1 7.89
CHEMBL440726 1 7.58
CHEMBL346188 1 7.55
CHEMBL357193 1 7.55
CHEMBL298695 1 7.47
CHEMBL151251 1 7.44
CHEMBL95108 1 7.43
CHEMBL153811 1 7.21
CHEMBL151252 1 7.08
CHEMBL146903 1 6.96
CHEMBL147246 1 6.64
CHEMBL151290 1 5.80
CHEMBL357274 1 5.65
CHEMBL356892 1 5.62
CHEMBL443295 1 -
CHEMBL356246 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL47529 IC50 = 13.0 nM 7.89
CHEMBL440726 IC50 = 26.0 nM 7.58
CHEMBL346188 IC50 = 28.0 nM 7.55
CHEMBL357193 IC50 = 28.0 nM 7.55
CHEMBL298695 IC50 = 34.0 nM 7.47
CHEMBL151251 IC50 = 36.0 nM 7.44
CHEMBL95108 IC50 = 37.0 nM 7.43
CHEMBL153811 IC50 = 61.0 nM 7.21
CHEMBL151252 IC50 = 84.0 nM 7.08
CHEMBL146903 IC50 = 110.0 nM 6.96
CHEMBL147246 IC50 = 230.0 nM 6.64
CHEMBL151290 IC50 = 1600.0 nM 5.80
CHEMBL357274 IC50 = 2230.0 nM 5.65
CHEMBL356892 IC50 = 2400.0 nM 5.62
CHEMBL443295 IC50 > 30000.0 nM -
CHEMBL356246 IC50 > 30000.0 nM -