Assay Detail
Functional
CHEMBL756959
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against tubulin assembly
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.13 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112192 | — | — | 1 | 6.37 |
| CHEMBL116173 | — | — | 1 | 6.17 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.85 |
| CHEMBL324797 | — | — | 1 | - |
| CHEMBL321632 | — | — | 1 | - |
| CHEMBL112385 | — | — | 1 | - |
| CHEMBL113332 | — | — | 1 | - |
| CHEMBL115488 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112192 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL116173 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL324797 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL321632 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL112385 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL113332 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL115488 | — | IC50 | < | 1000.0 | nM | - |