Assay Detail
Functional
CHEMBL756997
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity of compound on p24 production in peripheral blood mononuclear cells infected with HIV strain RT-MDR.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.90 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40631 | — | — | 1 | 8.40 |
| CHEMBL240416 | — | — | 1 | 8.30 |
| CHEMBL295585 | — | — | 1 | 8.30 |
| CHEMBL288626 | — | — | 1 | 7.70 |
| CHEMBL40625 | — | — | 1 | 7.70 |
| CHEMBL39999 | TROVIRDINE | 2.0 | 1 | 7.70 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 6.82 |
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 6.52 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 6.40 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.30 |
| CHEMBL290312 | — | — | 1 | 5.16 |
| CHEMBL40642 | — | — | 1 | 4.55 |
| CHEMBL296346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40631 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL240416 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL295585 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL288626 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL40625 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL39999 | TROVIRDINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL35033 | EMIVIRINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL290312 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL40642 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL296346 | — | IC50 | > | 1000.0 | nM | - |