Assay Detail
Functional
CHEMBL757000
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Inhibitory activity against induction of IL-1-beta release in PBMCs
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 6.70 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324977 | — | — | 1 | 7.82 |
| CHEMBL321494 | — | — | 1 | 7.52 |
| CHEMBL109580 | — | — | 1 | 7.51 |
| CHEMBL10 | SB-203580 | — | 1 | 7.43 |
| CHEMBL111364 | — | — | 1 | 7.41 |
| CHEMBL109732 | — | — | 1 | 7.40 |
| CHEMBL109331 | — | — | 1 | 7.39 |
| CHEMBL321415 | — | — | 1 | 7.36 |
| CHEMBL113419 | — | — | 1 | 7.36 |
| CHEMBL322296 | — | — | 1 | 7.35 |
| CHEMBL111210 | — | — | 1 | 7.33 |
| CHEMBL109695 | — | — | 1 | 7.25 |
| CHEMBL111053 | — | — | 1 | 7.15 |
| CHEMBL432798 | — | — | 1 | 7.12 |
| CHEMBL320695 | — | — | 1 | 7.09 |
| CHEMBL110263 | — | — | 1 | 7.07 |
| CHEMBL109028 | — | — | 1 | 6.97 |
| CHEMBL111067 | — | — | 1 | 6.92 |
| CHEMBL321404 | — | — | 1 | 6.82 |
| CHEMBL321676 | — | — | 1 | 6.82 |
| CHEMBL111211 | — | — | 1 | 6.82 |
| CHEMBL111422 | — | — | 1 | 6.75 |
| CHEMBL111644 | — | — | 1 | 6.70 |
| CHEMBL110947 | — | — | 1 | 6.64 |
| CHEMBL332021 | — | — | 1 | 6.57 |
| CHEMBL111403 | — | — | 1 | 6.52 |
| CHEMBL113060 | — | — | 1 | 6.46 |
| CHEMBL325597 | — | — | 1 | 6.44 |
| CHEMBL111456 | — | — | 1 | 6.42 |
| CHEMBL111052 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324977 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL321494 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL109580 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL10 | SB-203580 | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL111364 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL109732 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL109331 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL321415 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL113419 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL322296 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL111210 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL109695 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL111053 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL432798 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL320695 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL110263 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL109028 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL111067 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL321404 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL321676 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL111211 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL111422 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL111644 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL110947 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL332021 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL111403 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL113060 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL325597 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL111456 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL111052 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL109352 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL323734 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL109570 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL108757 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL113329 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL320130 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL323479 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL109383 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL111565 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL111566 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL321601 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL110262 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL110420 | — | IC50 | = | 7200.0 | nM | 5.14 |