Assay Detail
Functional
CHEMBL757001
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Inhibitory activity against TNF-alpha release in PBM cells
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBM |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.80 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324977 | — | — | 1 | 6.96 |
| CHEMBL111364 | — | — | 1 | 6.80 |
| CHEMBL109331 | — | — | 1 | 6.77 |
| CHEMBL321494 | — | — | 1 | 6.47 |
| CHEMBL109580 | — | — | 1 | 6.46 |
| CHEMBL321415 | — | — | 1 | 6.43 |
| CHEMBL111210 | — | — | 1 | 6.40 |
| CHEMBL321404 | — | — | 1 | 6.37 |
| CHEMBL111067 | — | — | 1 | 6.31 |
| CHEMBL321676 | — | — | 1 | 6.30 |
| CHEMBL320695 | — | — | 1 | 6.24 |
| CHEMBL10 | SB-203580 | — | 1 | 6.23 |
| CHEMBL111053 | — | — | 1 | 6.22 |
| CHEMBL109028 | — | — | 1 | 6.20 |
| CHEMBL109695 | — | — | 1 | 6.19 |
| CHEMBL111052 | — | — | 1 | 6.19 |
| CHEMBL110263 | — | — | 1 | 6.17 |
| CHEMBL110947 | — | — | 1 | 6.14 |
| CHEMBL113419 | — | — | 1 | 6.05 |
| CHEMBL109732 | — | — | 1 | 6.04 |
| CHEMBL111456 | — | — | 1 | 5.96 |
| CHEMBL432798 | — | — | 1 | 5.96 |
| CHEMBL325597 | — | — | 1 | 5.89 |
| CHEMBL111211 | — | — | 1 | 5.72 |
| CHEMBL109570 | — | — | 1 | 5.70 |
| CHEMBL109352 | — | — | 1 | 5.66 |
| CHEMBL113060 | — | — | 1 | 5.66 |
| CHEMBL322296 | — | — | 1 | 5.57 |
| CHEMBL111403 | — | — | 1 | 5.55 |
| CHEMBL320130 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324977 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL111364 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL109331 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL321494 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL109580 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL321415 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL111210 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL321404 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL111067 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL321676 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL320695 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL10 | SB-203580 | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL111053 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL109028 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL111052 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL109695 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL110263 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL110947 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL113419 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL109732 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL432798 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL111456 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL325597 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL111211 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL109570 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL109352 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL113060 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL322296 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL111403 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL320130 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL108757 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL332021 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL111644 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL323734 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL321601 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL113329 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL111566 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL111565 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL323479 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL111422 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL110420 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL110262 | — | IC50 | = | 40500.0 | nM | 4.39 |
| CHEMBL109383 | — | IC50 | = | 60000.0 | nM | 4.22 |