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Assay Detail

CHEMBL757045

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

P2Y purinoceptor 6 (CHEMBL4714)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Purine and pyrimidine (P2) receptors as drug targets.
Jacobson KA, Jarvis MF, Williams M.
J Med Chem (2002) 45 : 4057 -4093
PubMed 12213051 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 6 5.25 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL130266 URIDINE_DIPHOSPHATE 1 6.52
CHEMBL336296 URIDINE TRIPHOSPHATE 3.0 1 5.22
CHEMBL336208 1 4.00
CHEMBL3085531 1 -
CHEMBL129841 1 -
CHEMBL14249 ADENOSINE TRIPHOSPHATE 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL130266 URIDINE_DIPHOSPHATE EC50 = 300.0 nM 6.52
CHEMBL336296 URIDINE TRIPHOSPHATE EC50 = 6000.0 nM 5.22
CHEMBL336208 EC50 = 100000.0 nM 4.00
CHEMBL3085531 EC50 > 100000.0 nM -
CHEMBL129841 EC50 > 100000.0 nM -
CHEMBL14249 ADENOSINE TRIPHOSPHATE EC50 > 100000.0 nM -