Assay Detail
Binding
CHEMBL757106
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Binding affinity against Opioid receptor mu 1 using [3H][D-Ala2, MePhe4, Gly-ol5]-enkephalin as radioligand
11
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.51 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324236 | — | — | 1 | 7.85 |
| CHEMBL567175 | NALTRINDOLE | — | 1 | 7.82 |
| CHEMBL108076 | — | — | 1 | 7.03 |
| CHEMBL100729 | — | — | 3 | 6.89 |
| CHEMBL401093 | OXYMORPHINDOLE | — | 1 | 6.18 |
| CHEMBL13470 | SNC-80 | — | 1 | 5.89 |
| CHEMBL107670 | — | — | 3 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324236 | — | Ki | = | 14.1 | nM | 7.85 |
| CHEMBL567175 | NALTRINDOLE | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL108076 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL100729 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL100729 | — | Ki | = | 407.0 | nM | 6.39 |
| CHEMBL401093 | OXYMORPHINDOLE | Ki | = | 661.0 | nM | 6.18 |
| CHEMBL13470 | SNC-80 | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL107670 | — | Ki | = | 1631.0 | nM | 5.79 |
| CHEMBL107670 | — | Ki | = | 2093.0 | nM | 5.68 |
| CHEMBL107670 | — | Ki | = | 2618.0 | nM | 5.58 |
| CHEMBL100729 | — | Ki | > | 5000.0 | nM | - |