Assay Detail
Binding
CHEMBL757171
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Binding affinity for mouse opioid receptor mu
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Benzofuro[2,3-c]pyridin-6-ols: synthesis, affinity for opioid-receptor subtypes, and antinociceptive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.71 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592 | LEVORPHANOL | 4.0 | 1 | 9.52 |
| CHEMBL72180 | — | — | 1 | 9.05 |
| CHEMBL71301 | — | — | 1 | 8.89 |
| CHEMBL555891 | — | — | 1 | 8.40 |
| CHEMBL542150 | — | — | 1 | 7.77 |
| CHEMBL430441 | — | — | 1 | 7.72 |
| CHEMBL304616 | — | — | 1 | 7.52 |
| CHEMBL542881 | — | — | 1 | 7.51 |
| CHEMBL302977 | — | — | 1 | 7.30 |
| CHEMBL544292 | — | — | 1 | 7.14 |
| CHEMBL552619 | — | — | 1 | 7.00 |
| CHEMBL69559 | — | — | 1 | 6.90 |
| CHEMBL2114080 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592 | LEVORPHANOL | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL72180 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL71301 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL555891 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL542150 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL430441 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL304616 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL542881 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL302977 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL544292 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL552619 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL69559 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL2114080 | — | Ki | = | 2880.0 | nM | 5.54 |