Assay Detail
Functional
CHEMBL757204
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required to inhibit 50% of HIV-1 in peripheral blood mononuclear cells (PBMC)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Probing the mechanism of action and decomposition of amino acid phosphomonoester amidates of antiviral nucleoside prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 4.79 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105318 | ALOVUDINE | 2.0 | 1 | 6.00 |
| CHEMBL2021382 | — | — | 1 | 5.00 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 4.10 |
| CHEMBL52140 | — | — | 1 | 4.05 |
| CHEMBL112337 | — | — | 1 | - |
| CHEMBL300229 | — | — | 1 | - |
| CHEMBL432520 | — | — | 1 | - |
| CHEMBL53431 | — | — | 1 | - |
| CHEMBL326109 | — | — | 1 | - |
| CHEMBL115209 | — | — | 1 | - |
| CHEMBL323790 | — | — | 1 | - |
| CHEMBL300454 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105318 | ALOVUDINE | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2021382 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL52140 | — | EC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL112337 | — | EC50 | > | 210000.0 | nM | - |
| CHEMBL300229 | — | EC50 | = | 600000.0 | nM | - |
| CHEMBL432520 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL53431 | — | EC50 | = | 300000.0 | nM | - |
| CHEMBL326109 | — | EC50 | = | 200000.0 | nM | - |
| CHEMBL115209 | — | EC50 | = | 290000.0 | nM | - |
| CHEMBL323790 | — | EC50 | = | 900000.0 | nM | - |
| CHEMBL300454 | — | EC50 | = | 400000.0 | nM | - |