Assay Detail
Functional
CHEMBL757205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of concanavalin A stimulated T-cell proliferation in human PBMCs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.73 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 7.60 |
| CHEMBL273658 | — | — | 1 | 7.54 |
| CHEMBL8140 | — | — | 1 | 6.84 |
| CHEMBL440454 | — | — | 1 | 6.38 |
| CHEMBL8007 | — | — | 1 | 6.36 |
| CHEMBL267231 | — | — | 1 | 6.25 |
| CHEMBL266282 | AL-43 | — | 1 | 6.11 |
| CHEMBL267940 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL273658 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL8140 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL440454 | — | EC50 | = | 418.0 | nM | 6.38 |
| CHEMBL8007 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL267231 | — | EC50 | = | 563.0 | nM | 6.25 |
| CHEMBL266282 | AL-43 | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL267940 | — | EC50 | > | 1000.0 | nM | - |