Assay Detail
Binding
CHEMBL757322
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Evaluated for its concentration required for displacement of [3H]-Naloxone from opioid receptors in rat brain tissues
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.78 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304546 | — | — | 1 | 8.96 |
| CHEMBL141365 | — | — | 1 | 8.07 |
| CHEMBL140495 | — | — | 1 | 7.04 |
| CHEMBL343158 | — | — | 1 | 7.03 |
| CHEMBL344154 | — | — | 1 | 6.27 |
| CHEMBL140984 | — | — | 1 | 5.12 |
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304546 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL141365 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL140495 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL343158 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL344154 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL140984 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL9506 | DEVAZEPIDE | IC50 | = | 10000.0 | nM | 5.00 |