Assay Detail
Binding
CHEMBL757380
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Inhibition of Mu opioid receptor of mouse vas deferens
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.43 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436039 | — | — | 1 | 8.04 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 7.62 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 7.44 |
| CHEMBL163334 | — | — | 1 | 6.63 |
| CHEMBL349738 | — | — | 1 | - |
| CHEMBL355141 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436039 | — | IC50 | = | 9.15 | nM | 8.04 |
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL316446 | ENDOMORPHIN-1 | IC50 | = | 36.3 | nM | 7.44 |
| CHEMBL163334 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL349738 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL355141 | — | IC50 | > | 10000.0 | nM | - |