Assay Detail
Binding
CHEMBL757381
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Inhibitory potency against Opioid receptor mu 1 was determined in electrically induced strips of guinea pig ileum (GPI)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Ileum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.85 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339320 | — | — | 1 | 7.08 |
| CHEMBL340537 | — | — | 1 | 6.38 |
| CHEMBL129252 | — | — | 1 | 6.13 |
| CHEMBL31421 | — | — | 1 | 5.57 |
| CHEMBL340176 | — | — | 1 | 5.47 |
| CHEMBL338462 | — | — | 1 | 5.24 |
| CHEMBL341535 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339320 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL340537 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL129252 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL31421 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL340176 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL338462 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL341535 | — | IC50 | = | 8700.0 | nM | 5.06 |