Assay Detail
Binding
CHEMBL757491
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The compound was evaluated for binding affinity against opioid receptor mu in guinea pig brain membranes using [3H]- DAMGO as ligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Opioid agonist and antagonist activities of morphindoles related to naltrindole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.99 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | — | 1 | 8.42 |
| CHEMBL607339 | — | — | 1 | 6.76 |
| CHEMBL344000 | — | — | 1 | 6.43 |
| CHEMBL401093 | OXYMORPHINDOLE | — | 1 | 6.33 |
| CHEMBL47545 | — | — | 1 | - |
| CHEMBL607395 | — | — | 1 | - |
| CHEMBL607393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL607339 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL344000 | — | Ki | = | 375.0 | nM | 6.43 |
| CHEMBL401093 | OXYMORPHINDOLE | Ki | = | 468.0 | nM | 6.33 |
| CHEMBL47545 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL607395 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL607393 | — | Ki | > | 1000.0 | nM | - |