Assay Detail
Functional
CHEMBL757514
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity using strips of guinea pig ileum longitudinal muscle myenteric plexus.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.92 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13470 | SNC-80 | — | 1 | 5.26 |
| CHEMBL153648 | — | — | 1 | 5.07 |
| CHEMBL150609 | — | — | 1 | 5.01 |
| CHEMBL346625 | — | — | 1 | 4.69 |
| CHEMBL542267 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13470 | SNC-80 | IC50 | = | 5450.0 | nM | 5.26 |
| CHEMBL153648 | — | IC50 | = | 8580.0 | nM | 5.07 |
| CHEMBL150609 | — | IC50 | = | 9850.0 | nM | 5.01 |
| CHEMBL346625 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL542267 | — | IC50 | = | 27700.0 | nM | 4.56 |