Assay Detail
Functional
CHEMBL757516
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity for Opioid receptor mu 1 as inhibitory activity towards electrically stimulated guinea pig ileum
10
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.63 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340032 | DADLE | — | 1 | 7.54 |
| CHEMBL440123 | — | — | 1 | 6.06 |
| CHEMBL302454 | — | — | 2 | 5.71 |
| CHEMBL290301 | — | — | 1 | 5.68 |
| CHEMBL2111529 | — | — | 1 | 5.63 |
| CHEMBL13470 | SNC-80 | — | 1 | 5.26 |
| CHEMBL65348 | — | — | 2 | 5.17 |
| CHEMBL31421 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340032 | DADLE | IC50 | = | 28.8 | nM | 7.54 |
| CHEMBL440123 | — | IC50 | = | 862.0 | nM | 6.06 |
| CHEMBL302454 | — | IC50 | = | 1949.0 | nM | 5.71 |
| CHEMBL290301 | — | IC50 | = | 2073.0 | nM | 5.68 |
| CHEMBL2111529 | — | IC50 | = | 2345.0 | nM | 5.63 |
| CHEMBL302454 | — | IC50 | = | 2893.0 | nM | 5.54 |
| CHEMBL13470 | SNC-80 | IC50 | = | 5457.0 | nM | 5.26 |
| CHEMBL65348 | — | IC50 | = | 6767.0 | nM | 5.17 |
| CHEMBL31421 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL65348 | — | IC50 | = | 25901.0 | nM | 4.59 |