Assay Detail
Binding
CHEMBL757518
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Opioid receptor mu 1 in guinea pig brain homogenate using [3H]- PL-17 as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.98 | 10.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385759 | — | — | 1 | 10.57 |
| CHEMBL410616 | — | — | 1 | 9.44 |
| CHEMBL443068 | — | — | 1 | 9.01 |
| CHEMBL216640 | — | — | 1 | 8.97 |
| CHEMBL415330 | — | — | 1 | 8.89 |
| CHEMBL265824 | — | — | 1 | 8.64 |
| CHEMBL411557 | DYNORPHIN A (1-17) | — | 1 | 8.30 |
| CHEMBL384250 | — | — | 1 | 7.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385759 | — | IC50 | = | 0.027 | nM | 10.57 |
| CHEMBL410616 | — | IC50 | = | 0.362 | nM | 9.44 |
| CHEMBL443068 | — | IC50 | = | 0.986 | nM | 9.01 |
| CHEMBL216640 | — | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL415330 | — | IC50 | = | 1.29 | nM | 8.89 |
| CHEMBL265824 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL411557 | DYNORPHIN A (1-17) | IC50 | = | 5.04 | nM | 8.30 |
| CHEMBL384250 | — | IC50 | = | 10.3 | nM | 7.99 |