Assay Detail
Binding
CHEMBL757520
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Binding affinity towards Opioid receptor mu 1 was determined in guinea pig whole brain using [3H]CTOP radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The use of topographical constraints in receptor mapping: investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp-(N-Me)Nle-Asp-Phe-NH2 (SNF 9007), a cholecystokinin (26-33) analogue that binds to both CCK-B and delta-opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.50 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407057 | — | — | 1 | 6.16 |
| CHEMBL2112688 | — | — | 1 | 5.52 |
| CHEMBL2112689 | — | — | 1 | 5.17 |
| CHEMBL31421 | — | — | 1 | 5.14 |
| CHEMBL2111881 | — | — | 1 | - |
| CHEMBL2111882 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407057 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2112688 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL2112689 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL31421 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2111881 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2111882 | — | IC50 | > | 30000.0 | nM | - |