Assay Detail
Binding
CHEMBL757525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 of guinea pig brain membrane homogenates
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.99 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217049 | — | — | 1 | 10.10 |
| CHEMBL413011 | — | — | 1 | 8.47 |
| CHEMBL216640 | — | — | 1 | 8.00 |
| CHEMBL387083 | — | — | 1 | 7.92 |
| CHEMBL412600 | — | — | 1 | 6.92 |
| CHEMBL264733 | — | — | 1 | 6.54 |
| CHEMBL216182 | — | — | 1 | 6.51 |
| CHEMBL384485 | — | — | 1 | 6.40 |
| CHEMBL412580 | — | — | 1 | 6.26 |
| CHEMBL277132 | — | — | 1 | 6.18 |
| CHEMBL386170 | — | — | 1 | 6.13 |
| CHEMBL387437 | — | — | 1 | 5.88 |
| CHEMBL415339 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217049 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL413011 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL216640 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL387083 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL412600 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL264733 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL216182 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL384485 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL412580 | — | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL277132 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL386170 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL387437 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL415339 | — | IC50 | = | 2980.0 | nM | 5.53 |