Assay Detail
Binding
CHEMBL757529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Opioid receptor delta 1 receptor binding in ICR mouse brain membranes using the radioligand [3H]naltrindole
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pyrrolomorphinans as delta opioid receptor antagonists. The role of steric hindrance in conferring selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.15 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | — | 1 | 10.40 |
| CHEMBL60407 | — | — | 1 | 9.46 |
| CHEMBL60404 | — | — | 1 | 9.39 |
| CHEMBL305146 | — | — | 1 | 8.57 |
| CHEMBL303301 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL60407 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL60404 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL305146 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL303301 | — | Ki | = | 12.0 | nM | 7.92 |