Assay Detail
Binding
CHEMBL757530
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Opioid receptor delta 1 using [3H][D-Ala2, D-Leu5]-enkephalin as radioligand
11
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.21 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | — | 1 | 9.30 |
| CHEMBL401093 | OXYMORPHINDOLE | — | 1 | 9.10 |
| CHEMBL100729 | — | — | 3 | 9.05 |
| CHEMBL13470 | SNC-80 | — | 1 | 8.77 |
| CHEMBL324236 | — | — | 1 | 8.77 |
| CHEMBL108076 | — | — | 1 | 8.68 |
| CHEMBL107670 | — | — | 3 | 8.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL401093 | OXYMORPHINDOLE | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL100729 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL13470 | SNC-80 | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL324236 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL100729 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL108076 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL107670 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL107670 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL107670 | — | Ki | = | 1971.0 | nM | 5.71 |
| CHEMBL100729 | — | Ki | = | 3535.0 | nM | 5.45 |