Assay Detail
Binding
CHEMBL757536
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Binding affinity was measured on delta opioid receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
[2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.11 | 8.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436911 | — | — | 1 | 8.93 |
| CHEMBL216640 | — | — | 1 | 7.87 |
| CHEMBL573214 | NORBINALTORPHIMINE | — | 1 | 7.75 |
| CHEMBL414502 | — | — | 1 | 6.91 |
| CHEMBL506821 | — | — | 1 | 6.79 |
| CHEMBL407124 | — | — | 1 | 6.44 |
| CHEMBL414068 | — | — | 1 | 6.38 |
| CHEMBL216899 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436911 | — | Ki | = | 1.18 | nM | 8.93 |
| CHEMBL216640 | — | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL573214 | NORBINALTORPHIMINE | Ki | = | 17.7 | nM | 7.75 |
| CHEMBL414502 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL506821 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL407124 | — | Ki | = | 364.0 | nM | 6.44 |
| CHEMBL414068 | — | Ki | = | 419.0 | nM | 6.38 |
| CHEMBL216899 | — | Ki | = | 1500.0 | nM | 5.82 |