Assay Detail
Functional
CHEMBL757559
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Ability to inhibit the replication of A17 variant (Y181C,K103N) strain of HIV-1 p24 antigen production in PBMC
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.09 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL116474 | — | — | 1 | 5.48 |
| CHEMBL295585 | — | — | 1 | 4.39 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
| CHEMBL39999 | TROVIRDINE | 2.0 | 1 | - |
| CHEMBL69952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL116474 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL295585 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL593 | DELAVIRDINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL39999 | TROVIRDINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL69952 | — | IC50 | > | 100000.0 | nM | - |