Assay Detail
Functional
CHEMBL757563
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity by its ability to inhibit the replication of HIV-1 strain A17 (Y181C) in peripheral blood mononuclear cells (PBMC)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency virus-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.50 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.22 |
| CHEMBL330537 | — | — | 1 | 7.17 |
| CHEMBL92810 | — | — | 1 | 6.52 |
| CHEMBL39999 | TROVIRDINE | 2.0 | 1 | 6.30 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 4.30 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL330537 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL92810 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL39999 | TROVIRDINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL57 | NEVIRAPINE | IC50 | > | 100000.0 | nM | - |