Assay Detail
Functional
CHEMBL757706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity by using phytohemagglutininin-stimulated peripheral blood mononuclear cell(PHA/PBM) test system
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Lipophilic, acid-stable, adenosine deaminase-activated anti-HIV prodrugs for central nervous system delivery. 3. 6-Amino prodrugs of 2'-beta-fluoro-2',3'-dideoxyinosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.17 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 6.52 |
| CHEMBL501916 | LODENOSINE | 2.0 | 1 | 5.48 |
| CHEMBL279379 | — | — | 1 | 5.23 |
| CHEMBL42572 | — | — | 1 | 5.20 |
| CHEMBL295637 | — | — | 1 | 5.17 |
| CHEMBL42691 | — | — | 1 | 5.02 |
| CHEMBL43093 | — | — | 1 | 4.96 |
| CHEMBL39098 | — | — | 1 | 4.88 |
| CHEMBL42690 | — | — | 1 | 4.75 |
| CHEMBL433466 | — | — | 1 | 4.44 |
| CHEMBL296020 | — | — | 1 | - |
| CHEMBL297117 | — | — | 1 | - |
| CHEMBL274911 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1460 | DIDANOSINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL501916 | LODENOSINE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL279379 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL42572 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL295637 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL42691 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL43093 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL39098 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL42690 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL433466 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL296020 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL297117 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL274911 | — | IC50 | > | 5000.0 | nM | - |