Assay Detail
Functional
CHEMBL757712
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for inhibition of p24 production in HIV infected peripheral blood mononuclear cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5-Alkyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1H)-ones as potent non-nucleoside reverse transcriptase inhibitors of S-DABO series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.25 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 8.40 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL35655 | — | — | 1 | 8.00 |
| CHEMBL36031 | — | — | 1 | 6.10 |
| CHEMBL32386 | — | — | 1 | 5.35 |
| CHEMBL35755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35033 | EMIVIRINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL35655 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL36031 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL32386 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL35755 | — | IC50 | < | 1.0 | nM | - |