Assay Detail
Functional
CHEMBL757713
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Inhibit the replication of the HIV-1 strain HTLV111B in human peripheral blood mononuclear cell
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.04 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417737 | — | — | 1 | 9.00 |
| CHEMBL39999 | TROVIRDINE | 2.0 | 1 | 8.15 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 8.05 |
| CHEMBL292339 | — | — | 1 | 8.00 |
| CHEMBL432526 | — | — | 1 | 8.00 |
| CHEMBL302866 | — | — | 1 | 7.60 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.47 |
| CHEMBL416876 | — | — | 1 | - |
| CHEMBL291886 | — | — | 1 | - |
| CHEMBL305150 | — | — | 1 | - |
| CHEMBL434213 | — | — | 1 | - |
| CHEMBL63222 | — | — | 1 | - |
| CHEMBL65242 | — | — | 1 | - |
| CHEMBL295585 | — | — | 1 | - |
| CHEMBL304914 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417737 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL39999 | TROVIRDINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL292339 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL432526 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL302866 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL416876 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL291886 | — | IC50 | - | nM | - | |
| CHEMBL305150 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL434213 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL63222 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL65242 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL295585 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL304914 | — | IC50 | > | 1000.0 | nM | - |