Assay Detail
Functional
CHEMBL757720
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of IgE production on human PBMC culture after treating with IL-4, alpha-CD40, IL-10
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel naphthalene derivatives as inhibitors of human immunoglobulin E antibody production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.73 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423693 | — | — | 1 | 8.08 |
| CHEMBL130572 | — | — | 1 | 6.22 |
| CHEMBL130102 | — | — | 1 | 5.89 |
| CHEMBL130615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423693 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL130572 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL130102 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL130615 | — | IC50 | > | 3000.0 | nM | - |