Assay Detail
Functional
CHEMBL757754
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Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor delta-GAL4 chimeric receptor in transfected CV-1 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL2458) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.37 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124079 | — | — | 1 | 5.85 |
| CHEMBL278590 | GSK-9578 | — | 1 | 5.58 |
| CHEMBL124842 | — | — | 1 | 5.50 |
| CHEMBL340011 | — | — | 1 | 5.26 |
| CHEMBL125230 | — | — | 1 | 4.64 |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124079 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL278590 | GSK-9578 | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL124842 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL340011 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL125230 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL264374 | BEZAFIBRATE | EC50 | = | 110000.0 | nM | - |