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Assay Detail

CHEMBL757784

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested in vitro for the antiviral assay in mitogen stimulated human peripheral blood mononuclear (PBM) cells infected with HIV-1 (strain LAV)
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

The synthesis and anti-hiv activity of pyrimidine dioxolanyl nucleosides
Wilson LJ, Choi W, Spurling T, Liotta DC, Schinazi RF, Cannon D, Painter GR, St. Clair M, Furman PA
Bioorg Med Chem Lett (1993) 3 : 169 -174
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 6.11 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL505733 3 8.70
CHEMBL300793 1 8.30
CHEMBL297319 1 7.05
CHEMBL2115444 1 6.16
CHEMBL45897 1 5.77
CHEMBL303553 1 5.55
CHEMBL2115443 1 4.80
CHEMBL61323 1 4.54
CHEMBL46090 1 4.40
CHEMBL292278 1 4.24
CHEMBL49561 1 4.03
CHEMBL46089 1 -
CHEMBL301947 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL505733 EC50 = 2.0 nM 8.70
CHEMBL505733 EC50 = 2.0 nM 8.70
CHEMBL300793 EC50 = 5.0 nM 8.30
CHEMBL505733 EC50 = 60.0 nM 7.22
CHEMBL297319 EC50 = 90.0 nM 7.05
CHEMBL2115444 EC50 = 690.0 nM 6.16
CHEMBL45897 EC50 = 1700.0 nM 5.77
CHEMBL303553 EC50 = 2800.0 nM 5.55
CHEMBL2115443 EC50 = 15700.0 nM 4.80
CHEMBL61323 EC50 = 28500.0 nM 4.54
CHEMBL46090 EC50 = 39500.0 nM 4.40
CHEMBL292278 EC50 = 57500.0 nM 4.24
CHEMBL49561 EC50 = 93000.0 nM 4.03
CHEMBL46089 EC50 > 100000.0 nM -
CHEMBL301947 EC50 > 100000.0 nM -