Assay Detail
Binding
CHEMBL757878
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The opioid activity against the mu-receptor in the isolated guinea pig ileum(GPI)
7
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.09 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340032 | DADLE | — | 1 | 7.54 |
| CHEMBL285250 | — | — | 2 | 6.77 |
| CHEMBL290301 | — | — | 3 | 5.71 |
| CHEMBL31421 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340032 | DADLE | IC50 | = | 28.8 | nM | 7.54 |
| CHEMBL285250 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL285250 | — | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL290301 | — | IC50 | = | 1939.0 | nM | 5.71 |
| CHEMBL290301 | — | IC50 | = | 2073.0 | nM | 5.68 |
| CHEMBL290301 | — | IC50 | = | 2345.0 | nM | 5.63 |
| CHEMBL31421 | — | IC50 | = | 7300.0 | nM | 5.14 |