Assay Detail
Binding
CHEMBL757895
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Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5)
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL2304402) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.46 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL538498 | — | — | 1 | 9.66 |
| CHEMBL541818 | — | — | 1 | 9.41 |
| CHEMBL553371 | — | — | 1 | 9.00 |
| CHEMBL544289 | — | — | 1 | 8.96 |
| CHEMBL540539 | — | — | 1 | 8.92 |
| CHEMBL553786 | — | — | 1 | 8.51 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.41 |
| CHEMBL72423 | — | — | 1 | 8.30 |
| CHEMBL542878 | — | — | 1 | 8.07 |
| CHEMBL423125 | — | — | 1 | 7.85 |
| CHEMBL542394 | — | — | 1 | 7.75 |
| CHEMBL543818 | — | — | 1 | 7.70 |
| CHEMBL544995 | — | — | 1 | 7.68 |
| CHEMBL305206 | — | — | 1 | 7.58 |
| CHEMBL545221 | — | — | 1 | 7.57 |
| CHEMBL68106 | — | — | 1 | 7.52 |
| CHEMBL72875 | — | — | 1 | 7.27 |
| CHEMBL538505 | — | — | 1 | 7.01 |
| CHEMBL70382 | — | — | 1 | 6.96 |
| CHEMBL68388 | — | — | 1 | 6.77 |
| CHEMBL553083 | — | — | 1 | 6.66 |
| CHEMBL71478 | — | — | 1 | 6.64 |
| CHEMBL70432 | — | — | 1 | 6.64 |
| CHEMBL539519 | — | — | 1 | 6.60 |
| CHEMBL305028 | — | — | 1 | 6.42 |
| CHEMBL543351 | — | — | 1 | 6.31 |
| CHEMBL430421 | — | — | 1 | 6.24 |
| CHEMBL305427 | — | — | 1 | 6.05 |
| CHEMBL544057 | — | — | 1 | 5.72 |
| CHEMBL539010 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL538498 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL541818 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL553371 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL544289 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL540539 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL553786 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL72423 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL542878 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL423125 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL542394 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL543818 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL544995 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL305206 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL545221 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL68106 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL72875 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL538505 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL70382 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL68388 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL553083 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL71478 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL70432 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL539519 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL305028 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL543351 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL430421 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL305427 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL544057 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL539010 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL69502 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL71949 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL305014 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL539779 | — | IC50 | > | 10000.0 | nM | - |