Assay Detail
Binding
CHEMBL757897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE5 of human platelets
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.90 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266960 | — | — | 1 | 9.22 |
| CHEMBL8132 | — | — | 1 | 9.00 |
| CHEMBL269079 | — | — | 1 | 8.85 |
| CHEMBL8198 | — | — | 1 | 8.80 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.80 |
| CHEMBL8410 | — | — | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266960 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL8132 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL269079 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL8198 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL8410 | — | IC50 | = | 1.8 | nM | 8.74 |