Compound Detail
CHEMBL269079
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL269079 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WVLFZFWWAKSJLM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
445.9
MW (Da)
3.62
ALogP
7
HBA
3
HBD
101.3
PSA (Ų)
0.39
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 8.85 | 8.85 | 1.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 1.4 | nM | 8.85 | Inhibition of PDE5 of human platelets | 11297448 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11297448 | 10.1021/jm0155042 | Unchecked | 4 |
| 11297448 | 10.1021/jm0155042 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
| 11297448 | 10.1021/jm0155042 | Phosphodiesterase 3 and 5 (PDE3 and PDE5) | 1 |
Data from ChEMBL 36 via Core Engine