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Assay Detail

CHEMBL757961

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity in peripheral blood mononuclear cells (PBM).
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.
Kim HO, Ahn SK, Alves AJ, Beach JW, Jeong LS, Choi BG, Van Roey P, Schinazi RF, Chu CK.
J Med Chem (1992) 35 : 1987 -1995
PubMed 1597854 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.21 4.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL300793 1 4.21
CHEMBL300554 1 -
CHEMBL60438 1 -
CHEMBL61323 1 -
CHEMBL300589 1 -
CHEMBL58342 1 -
CHEMBL129 ZIDOVUDINE 4.0 1 -
CHEMBL292278 1 -
CHEMBL64278 1 -
CHEMBL64326 1 -
CHEMBL61386 1 -
CHEMBL64774 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL300793 IC50 = 62000.0 nM 4.21
CHEMBL300554 IC50 > 100000.0 nM -
CHEMBL60438 IC50 > 100000.0 nM -
CHEMBL61323 IC50 > 100000.0 nM -
CHEMBL300589 IC50 > 100000.0 nM -
CHEMBL58342 IC50 > 100000.0 nM -
CHEMBL129 ZIDOVUDINE IC50 > 100000.0 nM -
CHEMBL292278 IC50 > 100000.0 nM -
CHEMBL64278 IC50 > 100000.0 nM -
CHEMBL64326 IC50 > 100000.0 nM -
CHEMBL61386 IC50 > 100000.0 nM -
CHEMBL64774 IC50 > 100000.0 nM -