Assay Detail
Binding
CHEMBL757976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Opioid receptor mu 1 in rat brain membrane using [3H]DAGO as radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.27 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15595 | — | — | 1 | 8.03 |
| CHEMBL68177 | — | — | 1 | 8.02 |
| CHEMBL63407 | — | — | 1 | 7.98 |
| CHEMBL302408 | — | — | 1 | 7.96 |
| CHEMBL65047 | — | — | 1 | 7.92 |
| CHEMBL303513 | — | — | 1 | 7.66 |
| CHEMBL63235 | — | — | 1 | 7.61 |
| CHEMBL303418 | — | — | 1 | 6.56 |
| CHEMBL63972 | — | — | 1 | 5.52 |
| CHEMBL304431 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15595 | — | Ki | = | 9.43 | nM | 8.03 |
| CHEMBL68177 | — | Ki | = | 9.55 | nM | 8.02 |
| CHEMBL63407 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL302408 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL65047 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL303513 | — | Ki | = | 21.7 | nM | 7.66 |
| CHEMBL63235 | — | Ki | = | 24.8 | nM | 7.61 |
| CHEMBL303418 | — | Ki | = | 273.0 | nM | 6.56 |
| CHEMBL63972 | — | Ki | = | 3040.0 | nM | 5.52 |
| CHEMBL304431 | — | Ki | = | 3570.0 | nM | 5.45 |