Assay Detail
Binding
CHEMBL757988
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the binding affinity of Opioid receptor mu 1 by displacing the radioligand [3H]DAMGO from rat brain membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Beta-casomorphins: substitution of phenylalanine with beta-homo phenylalanine increases the mu-type opioid receptor affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.43 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38874 | DAMGO | — | 1 | 9.28 |
| CHEMBL3142988 | — | — | 1 | 6.14 |
| CHEMBL2370579 | — | — | 1 | 5.84 |
| CHEMBL2370515 | — | — | 1 | 5.79 |
| CHEMBL2370605 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38874 | DAMGO | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL3142988 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL2370579 | — | Ki | = | 1440.0 | nM | 5.84 |
| CHEMBL2370515 | — | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL2370605 | — | Ki | = | 7540.0 | nM | 5.12 |