Assay Detail
Binding
CHEMBL758067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Opioid receptor mu 1 of guinea pig ileum
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.31 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436039 | — | — | 1 | 8.46 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 8.04 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 8.00 |
| CHEMBL163334 | — | — | 1 | 7.05 |
| CHEMBL349738 | — | — | 1 | 6.23 |
| CHEMBL355141 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436039 | — | IC50 | = | 3.46 | nM | 8.46 |
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 9.22 | nM | 8.04 |
| CHEMBL316446 | ENDOMORPHIN-1 | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL163334 | — | IC50 | = | 89.9 | nM | 7.05 |
| CHEMBL349738 | — | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL355141 | — | IC50 | = | 816.0 | nM | 6.09 |