Assay Detail
Functional
CHEMBL758108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity of compound on agonist stimulated [35S]GTP-gamma-S binding on delta-opioid receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.54 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1237164 | NALTRINDOLE HYDROCHLORIDE | — | 1 | 10.52 |
| CHEMBL611702 | — | — | 1 | 9.17 |
| CHEMBL611697 | — | — | 1 | 8.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1237164 | NALTRINDOLE HYDROCHLORIDE | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL611702 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL611697 | — | Ki | = | 1.2 | nM | 8.92 |