Assay Detail
Binding
CHEMBL758126
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Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.47 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121403 | — | — | 1 | 10.22 |
| CHEMBL338510 | — | — | 1 | 10.10 |
| CHEMBL121494 | — | — | 1 | 9.89 |
| CHEMBL121211 | — | — | 2 | 9.82 |
| CHEMBL121060 | — | — | 1 | 8.54 |
| CHEMBL435380 | — | — | 1 | 8.23 |
| CHEMBL333410 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121403 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL338510 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL121494 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL121211 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL121060 | — | Ki | = | 2.89 | nM | 8.54 |
| CHEMBL435380 | — | Ki | = | 5.85 | nM | 8.23 |
| CHEMBL333410 | — | Ki | = | 0.005 | nM | - |
| CHEMBL121211 | — | Ki | = | 0.004 | nM | - |